How to Reduce the Risk of Exogenous Contamination in Cell Factories

Thu Jun 27 13:43:59 CST 2024

A cell factories is a multi-layered cell culture vessel primarily used in large-scale cell culture experiments. Preventing exogenous contamination is crucial during cell cultivation, as contamination can disrupt the experiment and cause irreparable damage. To reduce the risk of contamination, the following measures can be taken:

Cleaning and Disinfection: Before conducting any cell culture work, strict cleaning and disinfection protocols must be followed. Use appropriate cleaning agents and disinfectants, such as 70% ethanol or chlorine-based disinfectants, to clean and disinfect work surfaces, equipment, and tools. Ensure the work area is dry and tidy to minimize the growth of bacteria and fungi.

Aseptic Technique: Adhere strictly to aseptic techniques. This includes wearing appropriate protective equipment such as lab coats, gloves, masks, and goggles. Additionally, use sterile pipettes, culture vessels, and reagents to prevent introducing external contaminants into the cell culture environment.

Maintaining a Good Laboratory Environment: The laboratory should maintain proper temperature, humidity, and ventilation conditions to reduce the growth and spread of microorganisms. Regularly check the operational status of laboratory equipment to ensure they function correctly.

Specialized Piping Systems for Cell Factories: Utilize specialized piping systems for cell factories to achieve sealed liquid transfer, reducing the frequency of lid openings and significantly lowering the risk of exogenous contamination.

Personnel Training and Management: Provide regular training for laboratory personnel to improve their cell culture skills and awareness of aseptic techniques. Establish strict management protocols to ensure that laboratory personnel adhere to laboratory rules and operating procedures.

In summary, reducing the risk of exogenous contamination in cell factories requires rigorous cleaning and disinfection procedures, aseptic techniques, maintaining a good laboratory environment, using specialized piping systems, personnel training and management, as well as monitoring and maintenance measures. These measures need to be thoroughly implemented and maintained to ensure healthy cell growth and the accuracy of experimental results.

The FAI climbed 5.9 percent year-on-year in the first 11 months of 2018, quickening from the 5.7-percent growth in Jan-Oct, the National Bureau of Statistics (NBS) said Friday in an online statement.

The key indicator of investment, dubbed a major growth driver, hit the bottom in August and has since started to rebound steadily.

In the face of emerging economic challenges home and abroad, China has stepped up efforts to stabilize investment, in particular rolling out measures to motivate private investors and channel funds into infrastructure.

Friday's data showed private investment, accounting for more than 60 percent of the total FAI, expanded by a brisk 8.7 percent.

NBS spokesperson Mao Shengyong said funds into weak economic links registered rapid increases as investment in environmental protection and agriculture jumped 42 percent and 12.5 percent respectively, much faster than the average.

In breakdown, investment in high-tech and equipment manufacturing remained vigorous with 16.1-percent and 11.6-percent increases respectively in the first 11 months. Infrastructure investment gained 3.7 percent, staying flat. Investment in property development rose 9.7 percent, also unchanged.