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The α-Synuclein Seeding Amplification Assay for Parkinson’s Disease

Fri Sep 12 10:52:00 CST 2025

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Knocking on Cells’ Door: Strategic Approaches for miRNA and siRNA in Anticancer Therapy

Mon Sep 08 11:20:34 CST 2025

In this review, we provide an overview of recent advances involving small interfering RNAs (siRNAs) and microRNAs (miRNAs) in cancer therapy.

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Lentiviral Vectors: From Wild-Type Viruses to Efficient Multi-Functional Delivery Vectors

Wed Sep 03 09:45:51 CST 2025

Extensive studies about the human immunodeficiency virus type 1 (HIV-1) have allowed the generation of lentiviral vectors as gene delivery vehicles with enhanced safety and efficacy features. In this review, several strategies for controlling the molecular mechanisms occurring during the lentiviral vector manufacturing process are presented.

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Novel Drug Targets in Diastolic Heart Disease

Fri Aug 22 10:13:34 CST 2025

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Immunological Landscape and Molecular Therapeutic Targets of the Tumor Microenvironment in Hepatocellular Carcinoma

Wed Aug 20 17:28:36 CST 2025

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Efficient Genome Editing Using the T2A-Coupled Co-Expression of Two ZFN Monomers

Fri Aug 08 14:35:20 CST 2025

We herein showed that T2A-coupled ZF-ND1 monomers were co-expressed from a single expression cassette and that the corresponding ZF-ND1s efficiently cleaved the target DNA sequences.

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