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Cell Factory Tandem Operation Guide

Fri Feb 28 15:15:41 CST 2025

With the continuous development of biopharmaceuticals and cell culture technologies, cell factories have become key tools in industrial production. However, traditional single-operation cell factories face challenges such as long operational times and high contamination risks. Tandem operation offers an innovative solution to these problems.

Tandem operation connects multiple cell factories into a closed system, reducing the frequency of opening the containers, which in turn lowers the risk of external contamination. Additionally, tandem operation significantly improves production efficiency, allowing for easy liquid transfers and culture medium infusions between factories, thereby shortening the operation time of individual factories.

The steps for tandem operation are simple. First, disinfect with alcohol and perform the operation in a sterile environment. Next, install gas exchange kits, liquid transfer kits, and other accessories, using hose systems to connect the multiple factories. A peristaltic pump controls the liquid flow rate to ensure uniform supply of culture medium. By adjusting hose clamps appropriately, the liquid flow rate into each factory can be made consistent. Finally, a gas exchange system is used to maintain stable cultivation conditions by regulating ventilation and exhaust.

The closed system and the degree of automation in tandem operation significantly reduce the need for operator involvement, thereby lowering the risk of human error. For large-scale production enterprises, reducing operational time and improving efficiency means faster response to market demand, increased output, and ensuring that the production process remains uncontaminated, guaranteeing product quality and safety.

Tandem operation of cell factories provides significant production benefits in fields like biopharmaceuticals and cell culture. It not only enhances production efficiency but also reduces risks and improves product quality, making it an ideal choice for enterprises looking to optimize their production processes.

The FAI climbed 5.9 percent year-on-year in the first 11 months of 2018, quickening from the 5.7-percent growth in Jan-Oct, the National Bureau of Statistics (NBS) said Friday in an online statement.

The key indicator of investment, dubbed a major growth driver, hit the bottom in August and has since started to rebound steadily.

In the face of emerging economic challenges home and abroad, China has stepped up efforts to stabilize investment, in particular rolling out measures to motivate private investors and channel funds into infrastructure.

Friday's data showed private investment, accounting for more than 60 percent of the total FAI, expanded by a brisk 8.7 percent.

NBS spokesperson Mao Shengyong said funds into weak economic links registered rapid increases as investment in environmental protection and agriculture jumped 42 percent and 12.5 percent respectively, much faster than the average.

In breakdown, investment in high-tech and equipment manufacturing remained vigorous with 16.1-percent and 11.6-percent increases respectively in the first 11 months. Infrastructure investment gained 3.7 percent, staying flat. Investment in property development rose 9.7 percent, also unchanged.